Lives listing by nationality: Swiss
- Saladin d’Onex, Jean Louis (born 1701–died 1784), Swiss diplomat, politician
- Sales, Jean Louis (flourished c. 1769), Swiss [unknown occupation]
- Salis-Seewis, Johann Gaudenz von, baron von Salis-Seewis (born 1762–died 1834), Swiss army officer, poet
- Sandoz, Marie Frédérique Anne [née Bada] (born 1717–died 1792), Swiss salon hostess
- Sandoz, Montmollin Frères & Cie (active 1759–1767), Swiss trading firm
- Sandoz-Rollin, David Alphonse de (born 1740–died 1809), Swiss diplomat
- Sandoz de Rosières, François (born 1692–died 1779), Swiss aristocrat, politician
- Sarasin, Reverend Jean [senior] (born 1693–died 1760), Swiss churchman, Protestant
- Sarasin, Jean (born 1703–died 1778), Swiss churchman, Protestant
- Saussure, César François de (born 1705–died 1783), Swiss traveller
- Saussure, Horace Bénédict de (born 1740–died 1799), Swiss philosopher, scientist
- Saussure, Judith de (born 1710–died 1802), Swiss home-maker
- Saussure, Victor Benjamin Vespasien de (born 1737–died 1811), Swiss lawyer, judge, civil servant
- Schérer, Gaspard Henry (born 1728–died 1784), Swiss merchant
- Schinz, Heinrich (born 1726–died 1788), Swiss churchman, Protestant, author
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